携带t(11;14) 和1q放大功率的IgE血细胞白血病
Wataru Nakahara1, Takahito Ogawa1, Hitomi Matsunaga1
1Department of Hematology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan.
Case reports in hematology
|July 6, 2023
概括
IgE 血细胞瘤是一种罕见的癌症,通常具有标准风险的异常,但预后不佳. 这一案例凸显了共同存在的遗传变化对于了解疾病进展和指导治疗的重要性.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- IgE 血细胞瘤是一种罕见的血细胞瘤亚型.
- 它的特点是预后不好,细胞遗传异常的发病率高.
- 将t(11;14) 归类为多发性骨髓瘤的标准风险,与在IgE血细胞瘤中观察到的不良预后产生了差异.
研究的目的:
- 报告一个IgE原发性血细胞白血病病例与广泛的外骨干干涉.
- 为了研究这种攻击性亚型的细胞遗传特征.
- 探索IgE等离子体细胞瘤中共存遗传异常的含义.
主要方法:
- 关于IgE原发性血细胞白血病的病例报告.
- 血细胞透到肝脏,胃和淋巴结的病理确认.
- 细胞遗传学分析显示t(11;14) 和1q21放大.
主要成果:
- 该患者出现了IgE原发性血细胞白血病和外骨髓性病变.
- 细胞遗传学分析显示了t(11;14) 和1q21的放大.
- 标准化疗方案是无效的.
结论:
- 其他细胞遗传异常与t(11;14) 的同时存在可能在IgE血细胞瘤中至关重要.
- 调查并发的细胞遗传异常对于预后和理解疾病发病过程至关重要.
- 威尼托克拉克斯在治疗含有t(11;14) 的血细胞瘤方面表现有前途,这表明具有侵略性IgE亚型的潜力.
相关概念视频
01:10Antibody Structure
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...