女性的BMI对卵细胞基因表达模式有影响.
Zhiren Liu1,2,3, Mingting Jiang4, Xingting Chen1
1Center for Reproductive Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China.
Heliyon
|July 6, 2023
概括
异常的女性体重指数 (BMI) 通过改变基因表达而影响卵细胞质量. 较高的BMI (≥25 kg/m2) 可能会增强卵细胞对压力的抵抗力,在辅助生殖技术 (ART) 周期中可能改善胚胎质量.
科学领域:
- 生殖科学 生殖科学
- 基因组学就是基因组学.
- 不孕症研究 不孕症研究
背景情况:
- 女性肥胖与卵细胞质量降低和ART成功率有关.
- 人体质量指数 (BMI) 影响卵细胞质量的特定分子机制尚不完全理解.
- 研究基因表达模式可以了解BMI如何影响卵细胞生物学.
研究的目的:
- 阐明将异常女性BMI与改变卵细胞质量的机制.
- 为了确定改变基因表达模式是否会影响BMI对卵细胞的影响.
- 为了将这些分子变化与辅助生殖的临床结果相关联.
主要方法:
- 追溯临床结果分析,比较BMI≥25kg/m2和BMI≤20kg/m2的女性.
- 使用GSE87201数据集进行转录组分析,以比较卵细胞基因表达.
- 基因表达特征与细胞内精子注射 (ICSI) 周期的临床数据的相关性.
主要成果:
- 与BMI ≤20 kg/m2的女性相比,BMI ≥25 kg/m2的女性在第3天观察到显著更高的1-2级胚胎率.
- 来自BMI≥25 kg/m2的女性的卵子体表现出基因表达模式,表明对外源性压力的耐受性提高,例如ICSI.
- 这些分子发现为更高BMI组的第3天胚胎质量改善提供了潜在的解释.
结论:
- 异常的女性BMI通过对卵细胞基因表达的修改影响卵细胞质量.
- 尽管存在已知的风险,但BMI≥25 kg/m2可能会给卵细胞带来特定的优势,提高它们的弹性.
- 了解这些BMI介导的基因表达变化对于优化ART结果至关重要.
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