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高压空气可以动员人类的干细胞;对高压剂量曲线的新视角

Kent J MacLaughlin¹, Gregory P Barton², Rudolf K Braun¹

¹Department of Pediatrics, University of Wisconsin-Madison, Madison, WI, United States.

Frontiers in neurology

|July 6, 2023

概括

高压空气 (HBA) 疗法动员干细胞 (SPC),证明了其作为药物治疗的潜力. 这项研究建议重新评估以前使用HBA作为安慰剂的研究.

科学领域:

生理学生理学生理学
生物医学工程生物医学工程
细胞生物学细胞生物学

背景情况:

高压空气 (HBA) 在各种疾病中具有长期的药用历史.
现代高压氧气疗法 (HBOT) 使用100%的氧气,氧气被认为是动员干细胞 (SPC) 的活性元素.
含有氧和的HBA的治疗潜力以前没有被用于SPC调动的研究.

研究的目的:

研究高压空气 (HBA) 对干细胞前细胞 (SPC) 调动的影响.
评估HBA对细胞因子和化学因子表达的影响.
为了评估 HBA 暴露后全血细胞计的变化.

主要方法:

十名健康的志愿者被暴露在室内空气的1.27 ATA中,每天持续90分钟,持续两周 (10次暴露).
血液样本在不同的时间点收集:暴露前,第一次暴露后,第九次暴露前和最终暴露后72小时.
干细胞原始细胞 (SPC) 通过盲目的科学家使用流动细胞计量量化.

主要成果:

在9次HBA暴露 (p=0.02) 后,观察到SPC几乎增加了两倍.
在最后一次暴露72小时后,SPC水平增加了三倍 (p=0.008),表明持久的动员.
高压空气调节的细胞因子和化学因子表达 (详细数据不在摘要中提供).

结论:

高压空气 (HBA) 有效地调动干细胞 (SPC).
HBA显示出作为治疗治疗的潜力,需要进一步调查.
以往使用HBA作为安慰剂的研究应该根据这些发现重新评估.

关键词:

CD133 是一个CD133 CD133 是一个CD133 CD34+ CD34+ CD34+ CD34+ CD34+ CD34+ CD34+在这里,HBOT是HBOT.创伤性脑损伤创伤性脑损伤高压空气安慰剂退伍军人战争自伤自杀退伍军人战争自杀退伍军人自杀退伍军人心理痛苦的战争退伍军人

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