使用F-胆PET/CT检测复发部位在患有PSA衰竭的前列腺癌患者中
Dong-Yun Kim1, Won Woo Lee2, Yoo Sung Song2
1Department of Radiation Oncology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Prostate international
|July 6, 2023
概括
检测前列腺癌复发的最佳前列腺特异性抗原 (PSA) 水平使用18F-胆正子发射断层扫描-计算机断层扫描 (FCH-PET/CT) 至少为1.00 ng/mL. 较高的PSA水平,特别是在生化复发的情况下,增加了FCH-PET/CT检测率.
科学领域:
- 在瘤学瘤学.
- 核医学就是核医学.
- 放射学 放射学是一门学科.
背景情况:
- 使用18F-胆定子发射断层扫描-计算机断层扫描 (FCH-PET/CT) 检测前列腺癌复发是具有挑战性的,因为异质的失败模式.
- 在复发性前列腺癌中确定FCH-PET/CT成像的最佳前列腺特异性抗原 (PSA) 水平对于临床应用至关重要.
研究的目的:
- 为了评估前列腺癌患者患有PSA衰竭的FCH-PET/CT检测率.
- 为了确定执行FCH-PET/CT检测复发部位的最佳PSA值.
主要方法:
- 在激进治疗 (前列腺切除术或放射治疗) 后,对89名PSA衰竭患者进行了回顾性分析.
- 进行了FCH-PET/CT成像,并使用ROC分析分析检测率.
- 多变量后勤回归确定了影响FCH-PET/CT积极结果的因素,并对不同PSA故障模式进行了子组分析.
主要成果:
- 总体FCH-PET/CT检测率为59.6%,最佳PSA值为≥1.00 ng/mL.
- PSA > 1.00 ng/mL 显著预测了积极的发现,特别是远骨和骨盆外转移.
- 在生化复发 (BCR) 亚组中,PSA ≥1.75 ng/mL的AUC为0.82,远程转移的检测率更高.
结论:
- FCH-PET/CT在检测 PSA 衰竭超过特定值的患者前列腺癌复发时具有临床价值.
- 在初始治疗后对BCR患者进行FCH-PET/CT可以提高检测率,特别是远程传播.
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