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总血清FGF-21水平与内脏脂肪的积极关系不同于其功能完整的形式

Lucilla Crudele¹, Oihane Garcia-Irigoyen^1,2, Marica Cariello¹

¹Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Bari, Italy.

Frontiers in endocrinology

|July 6, 2023

概括

总纤维细胞生长因子-21 (FGF-21) 水平与内脏脂肪和代谢标志物相关,但完整的形式没有. 一个新的FGF-21切线识别了高血糖风险.

科学领域:

内分泌学在内分泌学.
代谢研究研究代谢研究
肥胖研究肥胖研究

背景情况:

纤维细胞生长因子-21 (FGF-21) 水平升高与肥胖有关.
内脏脂肪和FGF-21之间的关系需要进一步调查.

研究的目的:

探索内脏脂肪和血清FGF-21水平在具有代谢障碍的个体之间的关联.
为了确定总和完整的FGF-21形式是否与代谢参数相关.

主要方法:

血清总和完整的FGF-21度分别在51名和46名受试者中使用ELISA测量.
斯皮尔曼相关性被用来分析FGF-21水平和临床/生化代谢参数之间的关系.
在ROC分析中,评估了FGF-21对增加腰围 (WC) 的预测值.

主要成果:

在诸如内脏肥胖,代谢综合征或糖尿病等疾病中,FGF-21水平没有显著升高.
腰围 (WC) 与总FGF-21正相关,而高密度胆固醇和25-OH维生素D显示出负相关性.
总FGF-21切割值为161.47 pg/mL,预测 WC增加的个体的禁食血葡萄糖 (FPG) 受损;完整的FGF-21没有显示这种相关性.

结论:

总FGF-21水平与内脏脂肪和代谢功能障碍相关,这表明在代谢健康中发挥了作用.
完整的FGF-21和代谢参数之间缺乏相关性表明,功能性FGF-21可能与肥胖没有直接联系.
总FGF-21的新型切断值可以识别与内脏脂肪相关的高血糖症风险对象.

关键词:

在HDL胆固醇.完整的 FGF21 完整的 FGF21 内在的肥胖症内在的肥胖症维生素D是维生素D的重要组成部分.腰围腰围腰围腰围

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