相关实验视频
Updated: Jul 24, 2025

08:40
Chronic Salmonella Infection Induced Intestinal Fibrosis
Published on: September 22, 2019
7.2K
与普通人群相比,新诊断出克罗恩病和性结肠炎的人群中的肥胖率
Priya Sehgal1, Bo Shen2, Jianhua Li3
1Division of Digestive and Liver Diseases, Columbia University Irving Medical Center, New York, New York, USA.
Frontline gastroenterology
|July 6, 2023
概括
患有炎症性肠病 (IBD) 的年轻患者比普通人群肥胖的可能性更低. 被诊断为IBD的老年人更有可能肥胖,这表明肥胖是危险因素.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 肥胖是炎症性肠道疾病 (IBD) 的可修改风险因素.
- 了解早期和晚期IBD的体重指数 (BMI) 差异至关重要.
- 根据年龄调整的人口数据为IBD患者的BMI提供了背景.
研究的目的:
- 评估早期发病 (<18岁) 与晚发病 (≥65岁) IBD 患者的BMI.
- 为了比较IBD患者的BMI与年龄调整后的背景人口BMI.
- 调查肥胖症作为不同年龄组IBD的潜在风险因素.
主要方法:
- 在2000-2021年期间被诊断患有IBD的患者的回顾性分析.
- 早期发病IBD (<18岁) 和晚期发病IBD (≥65岁) 的分类.
- 肥胖被定义为BMI ≥30 kg/m2;来自社区调查的人口数据.
主要成果:
- 诊断时的BMI中位数为早期IBD的20kg/m2,而晚期IBD的26.9kg/m2 (p<0.01).
- 较年轻的IBD患者 (年龄<18) 与背景人群 (11.5%) 相比,肥胖率较低 (3.8-4.8%).
- 较老的IBD患者 (年龄≥65岁) 与背景人群 (23.6%) 相比,显示出更高的肥胖率 (24.3-29.5%).
结论:
- 在18岁以下被诊断患有IBD的患者比同龄人肥胖的可能性更低.
- 在≥65岁被诊断患有IBD的患者比同龄人更有可能肥胖.
- 肥胖可能是晚期IBD的可修改风险因素,需要进一步调查.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
299
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
299
Inflammatory Bowel Disease I: Ulcerative Colitis
223
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
223
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
357
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
357
Chronic Bowel Disorders: Introduction
489
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
489
Obesity
544
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
544
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
156
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
156

