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相关概念视频

Tumor Immunotherapy01:27

Tumor Immunotherapy

573
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
573
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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相关实验视频

Updated: Jul 24, 2025

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
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Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

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癌症免疫治疗研究和开发的微生理系统.

Yansong Peng1, Esak Lee1

  • 1Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY, 14853, USA.

Advanced biology
|July 6, 2023
PubMed
概括

微流体器官芯片系统为个性化癌症免疫疗法提供了一个有前途的途径,因为它可以更快地查和更好地了解瘤与免疫相互作用. 这些先进的模型旨在克服当前的治疗耐药性,并改善患者的治疗结果.

科学领域:

  • 生物医学工程 生物医学工程
  • 癌症研究 癌症研究
  • 免疫学 免疫学 免疫学

背景情况:

  • 癌症免疫疗法利用患者的免疫系统对抗癌症,有许多FDA批准的治疗方法可用.
  • 尽管取得了进展,但由于瘤遗传异质性和复杂的瘤免疫微环境,许多患者对当前的免疫疗法表现出耐药性.
  • 现有的药物查方法在准确反映体内条件方面存在局限性.

研究的目的:

  • 审查用于癌症免疫研究的微生理器官芯片 (OOC) 系统的最新进展.
  • 突出OOC技术在测试癌症免疫治疗剂中的应用.
  • 讨论将OOC技术转化为个性化免疫治疗中的临床应用的挑战和潜力.

主要方法:

  • 对用于癌症免疫研究开发的尖端微生理学OOC设备的审查.
  • 分析OOC系统用于选个性化免疫疗法.
  • 检查OOC模型以了解瘤与免疫相互作用.

主要成果:

  • OOC技术为研究癌症免疫提供了一个更现实的3D微环境.
  • 与传统方法相比,这些系统提供了更好的可控性,可重现性和生理相关性.
  • OOC平台有助于针对患者进行免疫治疗的特定查,并研究瘤免疫动态.
关键词:
工程T细胞治疗工程T细胞治疗免疫检查点封锁封锁免疫疗法 免疫疗法微生理系统的微生理系统.瘤免疫的微环境

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Last Updated: Jul 24, 2025

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结论:

  • 微流体OOC系统代表了癌症研究和药物开发的重大进步.
  • 这些技术在克服免疫疗法耐药性和实现个性化医疗方法方面具有巨大的潜力.
  • 需要进一步开发以应对广泛的免疫疗法应用临床翻译方面的挑战.