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近红外光增强生成基激素用于癌症免疫疗法

Qianqian Zhang^1,2, Yang Li^1,2, Chunhuan Jiang¹

¹State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.

Advanced healthcare materials

|July 6, 2023

概括

这项研究介绍了一种新型纳米平台,可以通过近红外光增强基 (•OH) 的生成,从而改善癌症免疫疗法. 这种策略有效地促进免疫细胞死亡,导致瘤消除和预防转移.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
在瘤学瘤学.

背景情况:

基基 (•OH) 是一种强有力的氧化剂,可以诱导免疫细胞死亡 (ICD),用于癌症治疗.
目前的癌症免疫疗法面临着挑战,因为瘤微环境中的OH生成效率低,导致免疫反应较弱.

研究的目的:

开发一种近红外 (NIR) 光增强策略,以促进•OH生成,以改善癌症免疫疗法.
为此目的,利用一个基于铜的金属有机框架 (Cu-DBC) 纳米平台.

主要方法:

制造一个基于铜的金属有机框架 (Cu-DBC) 纳米平台.
强化NIR光照射 •通过光热 (PT) 效应和光催化电子转移产生OH.
在体内评估OH生成效率,ICD诱导和抗瘤疗效.

主要成果:

与非辐射条件相比,NIR照射增加了7.34倍的OH产生效率.
Cu-DBC纳米平台有效诱导了强大的ICD,并放大了抗瘤免疫反应.
观察到显著的原发性瘤消除和抑制远部瘤生长和肺转移.

结论:

通过NIR光增强的Cu-DBC纳米平台提供了一个有前途的策略,用于促进OH生成和放大ICD,以有效的癌症免疫疗法.
这种方法解决了瘤微环境中低OH生成的局限性,为增强治疗结果铺平了道路.

关键词:

铁性化 (ferroptosis) 是一种基基是基基的重要组成部分.免疫原性细胞死亡免疫疗法免疫疗法接近红外光的近红外光.

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