探索冷保存在辅助生殖技术中的作用和潜在的表观遗传风险
Romualdo Sciorio1, Gerard Campos2, Luca Tramontano3
1Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, UK.
Zygote (Cambridge, England)
|July 6, 2023
概括
在辅助生殖过程中冷保存胚胎可能会破坏表观遗传重编程,可能会影响基因表达和长期后代健康. 需要进一步的研究来了解这些风险.
科学领域:
- 生殖生物学 生殖生物学
- 发展生物学 发展生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 自1978年以来,辅助生殖技术 (ART) 已经导致超过900万例分娩.
- 在胚胎早期发育过程中的表观遗传重编程对于正常发育至关重要.
- 人们担心在ART后,表观遗传异常增加,特别是印记障碍.
研究的目的:
- 批判性地审查证据,将胚胎冷保存与表观遗传调节联系起来.
- 评估冷保存对基因表达和后代健康的影响.
- 了解表观遗传修饰的潜在阴性干扰.
主要方法:
- 这篇叙事综述批判性地重新评估了现有的文学作品.
- 专注于胚胎冷保存和表观遗传调节之间的关联.
- 检查对基因表达和长期后代健康的影响.
主要成果:
- 表观遗传和转录基因特征对冷保存压力 (玻璃化) 敏感.
- 压力因素包括透性冲击,温度和pH值的变化,以及冷保护剂的毒性.
- 存在表观遗传修饰的未预期的阴性乱的可能性.
结论:
- 胚胎冷保存可能会诱导表观遗传失调.
- 这可能会影响基因表达,并可能导致后代的长期健康后果.
- 对这些风险的全面了解至关重要.
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