慢性电子烟使用和年轻人的动脉样硬化风险:一个横截面研究-简要报告
Theodoros Kelesidis1, Madhav Sharma1, Eashan Sharma1
1Division of Infectious Disease, Department of Medicine (T.K., M.S., E.S.), David Geffen School of Medicine at UCLA.
Arteriosclerosis, thrombosis, and vascular biology
|July 6, 2023
概括
电子烟 (ECIG) 和传统香烟 (TCIG) 增加了单细胞中的益风性变化. 与TCIG相比,ECIG的使用显示出类似的,但不那么严重的效应,表明潜在的心血管风险.
科学领域:
- 心血管科学 心血管科学
- 免疫学 免疫学 免疫学
- 毒理学 毒理学 毒理学
背景情况:
- 电子烟 (ECIG) 对动脉样硬化心血管疾病脆弱性的影响在很大程度上是未知的.
- 这项研究调查了ECIG的使用是否促进了益风性变化,特别是单细胞的透内皮迁移和泡细胞的形成.
研究的目的:
- 为了确定ECIG是否会增加单细胞中的动原性变化,使用ex vivo机械性动生成试验.
- 为了比较ECIG用户与传统香烟 (TCIG) 用户和非吸烟者的这些变化.
主要方法:
- 一项涉及健康非吸烟者,独家ECIG用户和独家TCIG用户的横截面研究.
- 使用了一个ex vivo模型与自身外周血液单核细胞和血.
- 通过流式细胞计量评估单细胞的超内皮迁移和单细胞衍生泡细胞的形成.
主要成果:
- 与非吸烟者相比,ECIG和TCIG使用者均表现出单细胞透内皮迁移和泡细胞形成的增加.
- 与ECIG用户相比,TCIG用户显示出这些益动原体变化的水平明显高.
- 曾经吸烟过的ECIG使用者比从未吸烟过的ECIG使用者有更高的改变.
结论:
- 外体检测有效地测量了益动原性变化,验证了其用于ECIG研究的用途.
- 与TCIG使用相比,ECIG使用与较不严重的益风性变化有关.
- 需要进一步的研究来区分残留吸烟影响和直接的ECIG影响.
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