左至右心室体积比和心力衰竭的结果与保存的喷射分数
Alberto Aimo1,2, Albert Teis3, Gizem Kasa3
1Scuola Superiore Sant'Anna.
Journal of cardiovascular medicine (Hagerstown, Md.)
|July 6, 2023
概括
左心室到右心室体积 (LRVR) 的比率可以预测心力衰竭的结果与保存的喷射分数 (HFpEF). 低于1.0或高于1.4的LRVR与HFpEF患者的死亡率和住院病例增加有关.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 心脏衰竭研究研究
背景情况:
- 对于左心室 (LV) 和右心室的体积,已经确立了特定于年龄和性别的参考值.
- 在心力衰竭中,LV与RV体积比率的预后意义与保存的喷射分数 (HFpEF) 仍然未评估.
研究的目的:
- 研究HFpEF患者左至右心室体积比率 (LRVR) 的预后影响.
- 确定LRVR是否可以作为HFpEF中不利结果的预测工具.
主要方法:
- 分析了来自159名HFpEF门诊患者 (2011-2021) 的心脏磁共振成像数据.
- 左向右心室体积比率 (LRVR) 被计算为LV终端透气体积指数 (LVEDVi) 与RV终端透气体积指数 (RVEDVi) 的比率.
- 患者的结果,包括全因死亡,心血管死亡和心力衰竭住院治疗,在平均3.5年的随访期间进行了跟踪.
主要成果:
- 中位数LRVR为1.21.
- 与LRVR1.0-1.3.3的患者相比,LRVR<1.0或LRVR≥1.4的患者有明显更高的全因死亡或心力衰竭住院的风险.
- 一个LRVR<1.0与5.95倍增加的风险相关 (HR5.95,P=0.006) 和一个LRVR≥1.4与4.10倍增加的风险相关 (HR4.10,P=0.004).
- 这些发现甚至在没有任何心室扩张的患者中也是一致的.
结论:
- 在1.0-1.4范围之外的LRVR值与HFpEF的预后较差有关.
- 在HFpEF患者中,LRVR为风险分层提供了一个潜在的新生物标志物.
- 这个比率可能成为预测HFpEF结果的有价值工具.
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