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哺乳动物大脑皮层中神经元密度的普遍逻辑正常分布

Aitor Morales-Gregorio^1,2, Alexander van Meegen^1,2, Sacha J van Albada^1,2

¹Institute of Neuroscience and Medicine (INM-6) and Institute for Advanced Simulation (IAS-6) and JARA-Institut Brain Structure-Function Relationships (INM-10), Jülich Research Centre, Wilhelm-Johnen-Str., 52428 Jülich, Germany.

Cerebral cortex (New York, N.Y. : 1991)

|July 6, 2023

概括

通过和哺乳动物皮层区域内的神经元密度遵循了逻辑正常分布. 这一发现揭示了大脑结构的基本组织原理,与简单的细胞分裂模型相一致.

科学领域:

神经科学是一个神经科学.
计算生物学计算生物学
大脑架构大脑架构

背景情况:

神经元数量和空间分布是大脑的关键特征.
神经元密度的统计分布在皮层细胞架构中基本上没有特征.

研究的目的:

描述神经元密度在哺乳动物皮层区域内的统计分布.
调查这些分布的基本原则.

主要方法:

在多种哺乳动物物种中,对多个皮层区域的细胞架构学数据的分析.
开发一种具有分布式增殖时间的细胞分裂最小模型.

主要成果:

在几种哺乳动物物种中,神经元密度在皮层区域中呈现逻辑正常分布.
这种逻辑正常分布也在单个皮质区域内观察到.
噪音细胞分裂模型解释了观察到的分布.

结论:

神经元密度的无处不在的逻辑正常分布是皮层细胞架构的一个新的组织原理.
这一发现与大脑中观察到的其他lognormal变量一致.
细胞分裂动态可能有助于观察到的神经元密度模式.

关键词:

细胞架构细胞架构逻辑正常分布逻辑正常分布数学模型是一个数学模型.神经发生神经发生.神经元密度的神经元密度

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