上升性大动脉尺寸对身体尺寸的正常化影响高血压患者的病理生理学相关性:坎帕尼亚健康网络
Costantino Mancusi1, Maria Virginia Manzi1, Maria Lembo1
1Hypertension Research Center, Department of Advanced Biomedical Science, Federico II University, Via S. Pansini 5, Naples 80131, Italy.
European journal of preventive cardiology
|July 6, 2023
概括
在高血压患者中,上升性大动脉 (AscAo) 的测量因方法而异. 根据身高规范的AscAo和AscAo (AscAo/HT) 显示生理一致性,并预测心血管风险,而不是根据身体表面积规范的AscAo (AscAo/BSA).
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 高血压研究 高血压研究
背景情况:
- 系统性高血压可能导致大动脉重塑.
- 准确测量上升性大动脉 (AscAo) 对于评估心血管风险至关重要.
- 不同的规范化方法 (例如身高,身体表面积) 可能会影响AscAo测量.
研究的目的:
- 评估治疗高血压患者上升大动脉 (AscAo) 测量结果的相关性和一致性.
- 为了比较AscAo的生理一致性,AscAo以身高正常化 (AscAo/HT) 和AscAo以身体表面积正常化 (AscAo/BSA).
- 评估这些大动脉测量与心血管结果的关联.
主要方法:
- 包括1634名经过治疗的高血压患者和可用的AscAo超声波.
- 通过使用前沿到前沿方法,在透析结束时测量AscAo.
- 研究了与人口统计和代谢概况的相关性;使用多变量回归和敏感性分析与心血管结果.
主要成果:
- AscAo,AscAo/HT和AscAo/BSA显示与年龄,eGFR,BP和HR的相关性相似.
- 肥胖和糖尿病与更高的AscAo和AscAo/HT相关,但AscAo/BSA较小.
- 扩展的AscAo和AscAo/HT,但不是AscAo/BSA,与心血管事件风险增加有显著关联.
结论:
- 在高血压患者中,大动脉重塑的大小取决于所使用的测量方法.
- 测量AscAo和AscAo/HT显示了生理的一致性.
- AscAo/BSA在生理上不那么一致,并且不能可靠地预测这一队列中的心血管风险.
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