治疗对HepG2肝细胞胰岛素耐药性的保护作用
Qingwen Zhang1, Shili Song2, Ruyue Jiang3
1Shanghai University of Medicine and Health Sciences.
Nutricion hospitalaria
|July 6, 2023
概括
(Mn) 通过减少氧化应激和增强关键信号通路,改善肝细胞中的胰岛素抵抗 (IR). 这项研究揭示了Mn Mn.
科学领域:
- 生物化学 生物化学
- 细胞生物学 细胞生物学
- 内分泌学 在内分泌学.
背景情况:
- (Mn) 与2型糖尿病和胰岛素抵抗 (IR) 有关,但其确切的机制尚不清楚.
- 研究Mn在IR中的作用对于理解代谢性疾病的发病过程至关重要.
研究的目的:
- 探索 (Mn) 对胰岛素抵抗 (IR) 的调节作用和机制.
- 使用由高棕酸盐 (PA),高葡萄糖 (HG) 或胰岛素诱导的肝细胞IR模型.
主要方法:
- 用PA,HG或胰岛素治疗HepG2细胞,有或没有Mn.
- 评估了胰岛素信号传递中的关键蛋白质,细胞内葡萄糖,葡萄糖积累,活性氧物种 (ROS) 水平和Mn超氧化物脱酶 (MnSOD) 活性.
主要成果:
- 在IR模型中,Mn逆转了酸化Akt,GSK-3β和FOXO1的减少表达.
- 抑制了细胞内葡萄糖含量的减少和葡萄糖积累的增加.
- 减少了过度的ROS产量,但没有改变MnSOD活性.
结论:
- 治疗改善了肝细胞中的胰岛素抵抗.
- 该机制涉及减少细胞内氧化应激,增强Akt/GSK-3β/FOXO1通路.
- 能促进糖原合成,抑制葡萄糖生成,提供潜在的治疗见解.
相关概念视频
01:26Oral Hypoglycemic Agents: Biguanides and Glitazones
238
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
238
01:23Dipeptidyl Peptidase 4 Inhibitors
214
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
214