对于二次恶性多叶病的高热内外体化疗
Daniel L Miller1, Christopher S Parks2, Brittany Ange1
1Medical College of Georgia, Augusta, Georgia, USA.
Journal of surgical oncology
|July 6, 2023
概括
针对二次恶性多发性肺部疾病 (SPD) 的手术后的高热内胸外化学疗法 (HITEC) 是安全的,并且耐受良好. 这种治疗有望改善晚期癌症的选定患者的生存率.
科学领域:
- 在瘤学瘤学.
- 胸部外科手术 胸部外科手术
- 医学瘤学 医学瘤学
背景情况:
- 胸腔转移 (二次恶性胸腔疾病 - SPD) 带来了非常糟糕的预后.
- 胸腔植入物的外科切除与胸内高热化疗相结合,可能会提高选择患者的生存率.
- 超热胸内外化学疗法 (HITEC) 是一种创新的方法,用于管理恶性多叶病.
研究的目的:
- 评估超热胸内外体外化疗 (HITEC) 的安全性和有效性.
- 评估HITEC的患者接受多切除/脱皮术 (P/D) 由于二次恶性多病 (SPD).
- 确定HITEC对患有恶性肺部疾病的患者的存活率和复发率的影响.
主要方法:
- 一项前性研究对101名患者进行了72个月的评估,其中35名患者接受了多切除/脱皮术 (P/D) 和60分钟的HITEC与cisplatin在42°C.
- 纳入标准包括单边膜扩散的成年人 (18-79岁),但不包括患有不受控制的原发性瘤,胸外转移或重大并发性疾病的人.
- 该程序涉及手术细胞减小,随后是手术内HITEC的管理.
主要成果:
- 没有观察到手术后死亡率. 18名患者 (51%) 出现了术后并发症,但没有患者出现功能衰竭或与西斯相关的毒性.
- 随访时间中位数为24个月. 总体生存率为61%,49%的人经历了中位数为12个月的复发.
- 11名患者 (31%) 平均17个月后死于转移性疾病. 在36个月后,没有发现复发.
结论:
- 二次性恶性肺病 (SPD) 的手术细胞减小,随后使用西斯的HITEC是一种耐受良好的治疗方式.
- 该研究表明没有与西斯相关的毒性,突出显示了HITEC在该患者队列中的安全性.
- 建议进行进一步的长期随访,以充分确定生存优势,并完善HITEC患者选择标准.
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