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来自性低温试验的估计膜过率:临床影响
Francis Lemire1, Dean A Fergusson2, Greg Knoll3,2
1Division of Urology, Department of Surgery, The Ottawa Hospital, Ottawa, ON, Canada.
BJU international
|July 6, 2023
概括
2009年估计的膜过率 (eGFR) 方程准确地估计了部分切除术 (PN) 后的功能,使其成为临床试验中测量GFR (mGFR) 的可行替代方案. 这种方法可以降低成本和患者负担.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 临床试验 临床试验
背景情况:
- 部分切除术 (PN) 试验需要精确评估功能.
- 测量膜过率 (mGFR) 是黄金标准,但很昂贵和繁.
- 估计的膜过率 (eGFR) 方程是潜在的替代方案.
研究的目的:
- 评估eGFR是否可以在PN试验中取代mGFR.
- 将不同的eGFR方程与mGFR的性能进行比较.
主要方法:
- 一个随机的性低温试验的后期分析.
- 患者接受了mGFR (DTPA血清除) 在手术前和1年后的PN.
- 使用2009年CKD-EPI肌素方程 (有/没有种族) 和2021年CKD-EPI方程计算eGFR.
- 由偏差,精度 (IQR) 和准确度 (在mGFR的30%以内) 评估的性能.
主要成果:
- 包括183名患者.
- 2009年eGFRcr (ASR) 和2009年eGFRcr (AS) 显示出最小的偏差和高精度,精度>90%在手术前和后.
- 2021年eGFRcr(AS) 的偏差和精度明显降低,准确度为手术前78.6%和手术后66.5%.
结论:
- 2009年eGFRcr(AS) 方程准确地估计了PN试验中的GFR.
- 这个方程可以作为mGFR的替代品.
- 使用2009 eGFRcr(AS) 可以降低PN试验中的成本和患者负担.
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