颗粒细胞输血是否可以帮助患有败血症的儿童癌症患者?
Swaminathan Keerthivasagam1, Shyam Srinivasan1, Anisha Navkudkar2
1Division of Pediatric oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Pediatric blood & cancer
|July 6, 2023
概括
颗粒细胞输血有助于清除患有严重败血症的儿科癌症患者的感染,包括由多药耐药生物体 (MDROs) 引起的感染. 这种方法提供了一种潜在的策略,以打击这种脆弱人群中的败血症死亡率.
科学领域:
- 儿科瘤学 儿科瘤学
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
背景情况:
- 败血症在儿童癌症患者中构成显著的死亡风险,由多药耐药生物体 (MDROs) 加剧.
- 强化化疗方案增加了患有血淋巴性恶性瘤的儿童对严重感染的易感性.
研究的目的:
- 评估颗粒细胞输血作为标准抗菌药物治疗严重败血症儿童癌症患者的辅助药物的疗效.
- 在涉及MDROs的病例中,评估颗粒细胞输血对生物体清除和死亡率的影响.
主要方法:
- 印度第三级癌症中心的回顾性研究 (2021年1月 - 2022年12月).
- 包括64名患有血淋巴性恶性瘤的儿童,在化疗后经历了75次严重败血症.
- 粒细胞输血与标准抗微生物治疗一起进行.
主要成果:
- 83%的血液培养证明的败血症病例是由MDROs引起的.
- 在70%的血液培养证明的血患者中,经过粒细胞输血后观察到有机体清除.
- 总体30天死亡率为25%,MDRO败血症患者的死亡率为32%.
结论:
- 颗粒细胞输血可能是儿童癌症患者严重败血症的有效辅助疗法,特别是那些患有MDRO感染的人.
- 这种干预措施在改善高风险患者群体的治疗结果和降低死亡率方面显示出前景.
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