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尿液等离子体降低了对胆囊细胞感染的允许性
Cesar Montelongo Hernandez1, Catherine Putonti2,3, Alan J Wolfe1
1Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Microbiology spectrum
|July 6, 2023
概括
大肠杆菌中的尿路等离子体可以降低对菌体感染的易感性,并保持抗生素耐药性. 这种相互作用通过潜在地选择抗生素耐药细菌来影响菌体疗法.
科学领域:
- 微生物学 微生物学
- 遗传学 遗传学 是一个
- 传染性疾病 传染性疾病
背景情况:
- 泌尿道是与人类健康相关的微生物群落 (urobiota) 的所在地.
- 菌体 (菌体) 和等离子体会影响体内细菌的动态.
- 尿路中的细菌,等离子体和菌体之间的相互作用尚未得到充分理解.
研究的目的:
- 为了描述尿液中的大肠杆菌等离子体.
- 调查这些等离子体在调节大肠感染的容许性中的作用.
- 探索这些相互作用对抗生素耐药性和菌体治疗的影响.
主要方法:
- 在尿路E. coli分离物中识别和预测F等离子体.
- 尿液中的大肠杆菌等离子体结合成大肠杆菌K-12菌株.
- 对实验室和尿路结核菌的跨结合剂允许性的评估.
主要成果:
- 在67个尿道大肠杆菌分离物中,有47个含有假定F等离子体,通常携带毒素-抗毒素,抗生素耐药性和毒性基因.
- 含有尿液等离子体的转结合性大肠杆菌K-12菌株对大肠杆菌感染的容许性降低.
- 在大肠杆菌K-12中,等离子体保持稳定,保持抗生素耐药性和减少菌体敏感性.
结论:
- 尿中的大肠杆菌F等离子体可以降低对大肠杆菌感染的易感性.
- 这些等离子体可能在维持尿路内的抗生素耐药性方面发挥作用.
- 菌体疗法可能无意中选择抗生素耐药菌株,这是由于等离子体介导的耐药性.
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