癌症流行病学研究的特点 采用代谢学研究:一个范围的综述
Catherine T Yu1, Zeinab Farhat2, Alicia A Livinski3
1Epidemiology and Genomics Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Rockville, Maryland.
概括
癌症流行病学研究越来越多地使用代谢学. 本综述强调了常见的方法,并确定了在未来研究中对标准化报告,多样化人口和更大的样本大小的需求.
科学领域:
- 代谢学 代谢学 代谢学
- 癌症流行病学 癌症流行病学
- 生物标志物发现发现
背景情况:
- 代谢学分析在癌症流行病学中越来越多地被使用.
- 了解当前的趋势对于推动该领域的发展至关重要.
- 本综述综合了有关癌症研究中的代谢学现有文献.
研究的目的:
- 描述癌症流行病学的研究设计,人口特征和代谢学方法的趋势.
- 确定未来在该领域增长和改进的机会.
- 为癌症研究中的代谢学现状提供全面的概述.
主要方法:
- 从1998年到2021年6月的文献范围审查.
- 搜索了PubMed/MEDLINE,Embase,Scopus和科学网. 这是一个很大的问题.
- 包括主要针对流行病学设计和每层≥100例癌症的研究.
主要成果:
- 包括77篇文章,重点关注结肠直肠,前列腺和乳腺癌.
- 嵌套病例控制设计和液体染色学-并联质谱法是常见的.
- 研究显示地理多样性,但缺乏标准化的种族/种族报告,并且经常有<300例.
结论:
- 需要改进的关键领域包括标准化的种族和种族报告.
- 在癌症代谢学研究中,需要更多多样化的研究群体.
- 未来的研究应该优先考虑更大的样本大小,以提高统计能力和通用性.
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