多发性硬化症肺功能障碍:在371人中进行的一项单中心观察性研究
Iván Murrieta-Álvarez1,2,3, José A Fernández-Gutiérrez1,2, Carlos A Pérez3
1Clínica Ruiz, Centro de Hematología y Medicina Interna, Puebla, México.
概括
多发性硬化症 (MS) 的肺功能异常随着疾病的进展而恶化. 中枢神经系统的损伤,特别是体的损伤,与MS患者的肺功能减弱有关.
科学领域:
- 神经学 神经学
- 肺部病理学 肺部病理学
- 放射学 放射学是一门学科.
背景情况:
- 多发性硬化症患者 (PwMS) 的肺功能异常可能源于肌肉虚弱或中枢神经系统 (CNS) 异常.
- 这些中枢神经系统异常可能会加剧MS中的运动和认知症状.
研究的目的:
- 调查PwMS中肺功能和中枢神经系统异常之间的关系.
- 探索特定的大脑病变与肺功能缺陷之间的关联.
主要方法:
- 这是一项涉及371名PwMS的横截面观察研究.
- 强制螺旋测量被用来评估肺功能 (FVC,FEV1,FEV1/FVC).
- 进行脑部MRI (定性和定量),以评估中枢神经系统的结构变化.
主要成果:
- 16-25%的PwMS表现出低的FVC和FEV1,在渐进的MS亚型中更高的流行率.
- 体T2-FLAIR病变与减少的FVC和FEV1 (OR 3.62,p=0.012) 显著相关,特别是在RRMS (OR 10.1,p=0.031) 中.
- 增加的FVCz-score与较大的海马体积有关 (0.25厘米3对于整体海马体,0.43厘米3对于左海马体).
结论:
- 异常的肺功能测试随着MS病程的恶化 (RRMS到PPMS/SPMS) 逐渐增加.
- 中枢神经系统的病变,特别是体的病变,在PwMS中与肺功能受损有关.
- 在MS中,肺功能 (FVC) 和海马体体积之间存在正相关性.
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