立方体不容忍:美国和国际指导的概述
Mary Katherine Cheeley1, Katarina Clegg2,3, Connor Lockridge1
1Grady Health System, Atlanta, GA, 30303, USA.
Current atherosclerosis reports
|July 6, 2023
概括
大多数患者可以耐受他类药物治疗,这对于减少心血管疾病至关重要. 对于那些患有他类药物不耐受或他类药物相关肌肉症状 (SAMS) 的人来说,评估,教育和替代治疗是关键.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 类固醇药物治疗对于减少动脉样硬化心血管疾病 (ASCVD) 和死亡率至关重要.
- 静止素不耐受和与静止素相关的肌肉症状 (SAMS) 可以阻碍治疗的坚持和有效性.
- 国际和国内组织已经制定了管理他类药物不耐受性的指导方针.
研究的目的:
- 审查目前对他类药物不耐受症的定义,考虑和治疗算法.
- 为了特别解决与他类药物相关的肌肉症状 (SAMS).
主要方法:
- 审查最近的国际和国内指导文件.
- 综合共同的主题和管理策略的差异.
主要成果:
- 大多数患者可以耐受他类药物;然而,存在管理不耐受性的策略.
- 关键的管理步骤包括评估,患者教育,治疗药物监测和重新挑战他类药物治疗.
- 对于那些不能耐受他类药物的高风险患者来说,非他类药物治疗非常重要.
- 关于实验室监测和SAMS分类的指南存在差异.
结论:
- 类固醇药物治疗仍然是预防ASCVD的降脂治疗的基石.
- 对他类药物不耐受性的有效管理对于确保治疗坚持和实现脂质目标至关重要.
- 需要进一步的研究,以便对SAMS进行一致的诊断和电子健康记录识别.
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