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肺癌的风险得分永远永远永远在中国的吸烟者
Zhimin Ma1,2,3, Jun Lv4,5, Meng Zhu1,2
1Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu, P. R. China.
Cancer communications (London, England)
|July 6, 2023
概括
一个新的肺癌风险评分 (LCRS) 有效地评估了广泛的年龄范围内的曾经和从未吸烟者的风险. 这种在亚洲队伍中开发的工具有助于个性化预测肺癌风险.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 在瘤学瘤学.
背景情况:
- 现有的肺癌风险模型主要关注欧洲/北美人口和老年人.
- 关于亚洲人群肺癌风险概况的数据有限,特别是在从未吸烟者和50岁以下的人群中.
研究的目的:
- 开发和验证一个肺癌风险估计工具,适用于各种年龄组的曾经和从未吸烟者.
- 解决肺癌研究中代表性不足的人群风险预测的差距.
主要方法:
- 利用中国Kadoorie生物银行队列来识别预测因素和模型肺癌风险.
- 为159,715名一直吸烟者和336,526名从未吸烟者开发了单独的肺癌风险评分 (LCRS).
- 在14,153名从未吸烟者和5,890名曾经吸烟者的独立队列中验证了LCRS.
主要成果:
- 确定了13个常吸烟者和9个从未吸烟者的关键预测因素,观察到吸烟强度和戒烟的非线性关联.
- 长期吸烟率表现出良好的预测性能,在导出队列中,曲线下的面积值为0.778 (曾经吸烟者) 和0.733 (从未吸烟者).
- 该工具准确地分层风险,显示在过去10年中,在曾经吸烟者和从未吸烟者中,低LCRS类别和高LCRS类别的累积肺癌发病率显著不同.
结论:
- 肺癌风险评分 (LCRS) 作为一个验证和有效的工具来评估30-80岁的个体的肺癌风险.
- 开发的在线风险评估工具 (LCKEY) 便于临床医生和研究人员实际应用LCRS.
- 该研究强调了针对不同人群的量身定制风险评估的重要性,包括从未吸烟者和年轻人.
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