系统性西斯普拉丁增加了呈阳性偏频掩盖声度测试患者的数量
Harukazu Hiraumi1, Shin-Ichi Oikawa1, Kiyoto Shiga1
1Department of Otolaryngology-Head and Neck Surgery, Iwate Medical University, Yahaba, Shiwa, Iwate, Japan.
PloS one
|July 6, 2023
概括
系统性西斯普拉丁的使用会对听力产生负面影响,正如非频率掩盖听力测试的异常结果所证明的那样. 这种效应,特别是在像250 Hz这样的较低频率下,是剂量依赖的,表明有明显的耳毒性风险.
科学领域:
- 化疗的耳毒性作用 化疗的耳毒性作用
- 听力学评估技术 听力学评估技术
- 癌症治疗副作用 癌症治疗副作用
背景情况:
- 西斯是一种广泛使用的化疗剂.
- 耳毒性是西斯普拉丁已知的副作用之一,影响听力.
- 非频率掩盖听力测量是一种专门的听力测试.
研究的目的:
- 为了评估系统性思普拉丁对听力的影响,使用非频率掩盖声度计.
- 评估在西斯治疗前后听觉值的变化.
- 为了确定观察到的听力变化是否依赖于剂量.
主要方法:
- 分析了26名接受系统性思普拉丁的患者 (48只耳朵).
- 使用70 dBHL的带通噪声以1000 Hz为中心进行了非频率掩盖声度测试.
- 听觉值与标准纯色调听力测量相比较;>10dB的升高被认为是显著的.
主要成果:
- 在使用西斯之前,正常的非频率掩盖听力测试结果很高 (例如,在250Hz时93.8%).
- 在服用西斯后,异常结果增加,特别是在较低频率时.
- 在250Hz (p=0.01) 观察到统计学上显著的变化,正常结果在治疗后降至70.5%.
结论:
- 系统性西斯普拉丁的使用导致可测量的听力损伤.
- 非频率掩饰声学可以检测西斯胺诱导的耳毒性.
- 西斯丁的耳毒性作用似乎取决于剂量,在某些频率下更为明显.
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