基于根和根茎的草药中的296种农药多重残留物与GC-MS/MS的同时分析方法
Seung-Hyun Yang1,2, Yongho Shin3, Hoon Choi1
1Department of Life & Environmental Sciences, College of Agriculture and Food Sciences, Wonkwang University, Iksan, Republic of Korea.
PloS one
|July 6, 2023
概括
一种新的方法可以准确地检测传统草药中的多种农药残留物,如Cnidium officinale,Rehmannia glutinosa和Paeonia lactiflora,使用气色谱-并联质谱法 (GC-MS/MS). 这种分析确保了常用的草药产品的安全性.
科学领域:
- 分析化学 分析化学
- 食品科学 食品科学 食品科学
- 药理学是指药理学,即药理学是指药理学.
背景情况:
- 草药越来越受欢迎,但可能被农药残留污染.
- 确保根/根茎的传统药物的安全性,如Cnidium officinale,Rehmannia glutinosa和Paeonia lactiflora,需要强大的分析方法.
- 对多种农药的同时分析对于全面的安全评估至关重要.
研究的目的:
- 开发和验证农药多重残留物的同时分析方法.
- 为了分析三种特定的草药中的农药污染:Cnidium officinale,Rehmannia glutinosa和Paeonia lactiflora.
- 确保商用草药产品的安全性和质量.
主要方法:
- 开发了一种使用气相色谱-并联质谱 (GC-MS/MS) 的方法.
- 采用乙酸/乙烯酸提取,硫酸/化物分离,以及Oasis PRiME HLB加光净化.
- 使用聚散固体相提取与氧化清理和多重反应监测 (MRM) 进行分析.
主要成果:
- 在296种目标农药中达到0.002-0.05毫克/千克的量限 (LOQ).
- 证明了高恢复率 (77.7-88.5%) 在70%和120%之间,RSDs ≤20%.
- 在现实世界草药样本中成功量化了10种农药残留物.
结论:
- 开发的GC-MS/MS方法对于在草药中同时进行农药残留分析是可靠和有效的.
- 这种方法可以有效地评估Cnidium officinale,Rehmannia glutinosa和Paeonia lactiflora的安全性.
- 这些发现有助于在草药产品市场的质量控制和消费者安全.
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