之前的简单疹病毒感染和疹疹的风险
Ruth Harbecke1,2, Michael N Oxman1,2,3, Stacy Selke4
1Department of Veterans Affairs San Diego Healthcare System, San Diego, California, USA.
The Journal of infectious diseases
|July 6, 2023
概括
之前的单纯疹病毒 (HSV) 感染可能会对疹病毒 (HZ) 提供保护. 没有先前感染HSV的个体患上HZ的风险明显更高.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 在美国,带状疹 (HZ) 发病率正在上升,与简单疹病毒 (HSV) 流行率的下降相吻合.
- 一个假设表明,从HSV到疹病毒 (VZV) 的交叉免疫力降低会增加HZ风险.
研究的目的:
- 调查先前的HSV感染是否在患有HZ的人群中不太常见.
- 为了确定HSV病毒阳性和HSV病毒阴性个体之间的HZ严重程度是否不同.
主要方法:
- 一项嵌套病例控制研究比较了HSV-1和HSV-2血清流行率.
- 病例是确诊HZ的个人;对照组是匹配没有HZ的个人.
主要成果:
- 在639名参与者中,75%的人发现HSV血清阳性.
- 在HZ病例中,HSV血清阴性明显高 (30.5%),而不是对照组 (22.3%),表明HZ风险增加了55%.
- 之前的HSV感染与不太严重的HZ有关.
结论:
- 以前感染HSV可以在一定程度上保护人免受疹.
- 这一发现凸显了交叉反应性免疫在HZ病变发生中的潜在作用.
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