新阴道人类乳头瘤病毒在变性女性个体中的流行:系统性审查
Devika Nandwana1, Kenna Hawes, Christina Farr Zuend
1School of Medicine and the Center for Global Health and Diseases, Department of Pathology, School of Medicine, Case Western Reserve University, and University Hospitals Urology Institute, Cleveland, Ohio.
Obstetrics and gynecology
|July 6, 2023
概括
经过阴道整形的变性女性可能会患上高风险的人类乳头瘤病毒 (hrHPV) 感染以及新阴道的相关异常. 需要进一步的研究来制定针对这一群体的查指南.
科学领域:
- 妇科瘤学 妇科瘤学
- 传染性疾病 传染性疾病
- 跨性别者健康 跨性别者健康
背景情况:
- 阴道造形术是针对变女性个体的手术程序,创建一个新阴道.
- 人类乳头瘤病毒 (HPV) 是一种常见的感染,可以导致各种健康问题,包括癌症.
- 新阴道的长期HPV状况需要进一步调查,以告知患者的护理.
研究的目的:
- 为了确定高风险人类乳头瘤病毒 (hrHPV) 和HPV相关异常在后阴道造形转化女性患者的新阴道的患病率.
- 为这个人群制定潜在的HPV查指南提供信息.
主要方法:
- 在多个数据库 (MEDLINE,ClinicalTrials.gov,Cochrane Library,Scopus,Google Scholar) 进行了系统的文献搜索,截至2022年9月30日.
- 包括的研究包括随机临床试验,队列研究,横截面研究和英语病例报告,重点关注患有HPV诊断或新阴道病变的转女性个体.
- 数据提取和选由两名独立审查员进行,并对所包含的研究进行了质量和偏差风险评估.
主要成果:
- 十五项研究符合最初59个摘要的纳入标准.
- 在已识别的研究中,新阴道性HPV的患病率从8.3%到20%不等.
- 在每项研究中,与HPV相关的新阴道异常的患病率在0%至8.3%之间.
结论:
- 阴道造形术后的变性女性有新阴道HPV感染和相关异常的风险.
- 目前的证据受到缺乏高档研究的限制,需要更严格的研究.
- 更好地了解新阴道HPV患病率对于制定有效的查和预防性护理指南至关重要.
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