静电化疗模型中脉冲重复率的影响
Raul Guedert1, Guilherme Brasil Pintarelli2, Fátima Regina Mena Barreto Silva3
1Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Bioelectrochemistry (Amsterdam, Netherlands)
|July 6, 2023
概括
在电穿孔中增加脉冲重复率显著改变了组织中的电流大小. 这一发现凸显了电化学治疗研究中需要动态模型和精确的协议签名的需要.
科学领域:
- 生物物理学的生物物理.
- 生物医学工程 生物医学工程
- 医学物理 医学物理
背景情况:
- 电穿孔使用脉冲电场 (PEF) 来改变细胞膜和组织的电特性.
- 静态模型通常用于解释这些电变化,但可能无法捕捉动态效应.
- 电脉冲重复率对组织电气性质的作用尚未完全理解.
研究的目的:
- 为了研究电穿孔过程中电脉冲重复率增加对电流大小的影响.
- 评估重复率对肝脏,口腔粘膜和肌肉组织的影响.
- 评估动态模型分析电穿孔协议的必要性.
主要方法:
- 在肝脏,口腔粘膜和肌肉组织上进行了ex vivo动物实验.
- 电脉冲的重复率从1Hz到5kHz不等.
- 在不同的重复率下测量电流的大小.
主要成果:
- 观察到电流大小显著增加,重复率更高 (1 Hz 到 5 kHz).
- 观察到的增加是肝脏的10.8%,口腔粘膜的5.8%,肌肉的4.7%.
- 校正系数可以将模型误差降低到不到1%,但动态模型可能是必要的.
结论:
- 电脉冲重复率是电穿孔过程中影响电流的关键参数.
- 静态模型可能会导致不准确,如果它们不考虑PEF签名,特别是重复率.
- 在预处理计算机研究中,建议使用动态模型来准确分析变化的电穿孔协议签名.
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