在帕金森病的早期阶段使用剑桥脑科学认知平台评估认知障碍
Maryam Hosseini1, Afshin Borhani-Haghighi2, Peyman Petramfar2
1Department of Neuroscience, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran; DANA Brain Health Institute, Iranian Neuroscience Society-Fars Branch, Shiraz, Iran.
Clinical neurology and neurosurgery
|July 6, 2023
概括
早期帕金森病 (PD) 患者在记忆,注意力和推理方面表现出认知缺陷,独立于嗅觉功能. 剑桥脑科学认知平台 (CBS-CP) 有效评估这些早期认知障碍.
科学领域:
- 神经学 神经学
- 认知神经科学 认知神经科学
背景情况:
- 非运动症状,包括认知障碍,在帕金森病 (PD) 中很普遍,影响生活质量.
- 早期PD的认知障碍及其与嗅觉症状的关系仍未得到充分研究.
- 准确评估认知功能在早期的PD对于及时干预至关重要.
研究的目的:
- 用剑桥脑科学认知平台 (CBS-CP) 评估早期帕金森病 (PD) 患者的认知表现.
- 探索早期PD认知障碍和嗅觉功能之间的关系.
- 评估CBS-CP在早期PD中检测认知缺陷的实用性,特别是当MMSE得分正常时.
主要方法:
- 招募了34名参与者,包括患有PD的个人和健康对照 (HCs).
- 使用CBS-CP和迷你精神状态检查 (MMSE) 评估认知功能.
- 嗅觉功能使用标准化嗅觉快速嗅觉测试 (QST) 来测量.
主要成果:
- 与HC相比,PD患者在所有CBS-CP任务中表现明显差,包括短期记忆,注意力和推理能力.
- 在PD患者和HC患者之间没有观察到口头领域任务得分的显著差异.
- 虽然PD患者的MMSE得分处于正常范围内,但PD和HC组之间存在显著差异;PD患者的认知障碍和嗅觉功能之间没有发现相关性.
结论:
- CBS-CP是评估早期PD认知障碍的可靠工具,即使MMSE得分正常.
- 在帕金森病的早期阶段,认知和嗅觉障碍似乎是独立的.
- 使用CBS-CP的进一步研究可以帮助理解和管理PD的非运动症状.
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