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Updated: Jul 24, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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作为HA-CD44相互作用抑制剂的N-aryltetrahydroisoquinoline衍生物:设计,合成,计算研究和抗瘤作用

Jose M Espejo-Román1, Belén Rubio-Ruiz1, Meriem Chayah-Ghaddab1

  • 1Department of Medicinal and Organic Chemistry and Excellence Research Unit of Chemistry Applied to Biomedicine and the Environment, Faculty of Pharmacy, Campus Cartuja s/n, 18071, University of Granada, Granada, Spain; GENYO, Centre for Genomics and Oncological Research, Pfizer/University of Granada/Andalusian Regional Government, PTS Granada, Avda. Ilustración 114, 18016, Granada, Spain; Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), SAS-University of Granada, Avenida de Madrid, 15, 18012, Granada, Spain.

European journal of medicinal chemistry
|July 6, 2023
PubMed
概括

研究人员开发了针对氨酸 (HA) 和分化44 (CD44) 相互作用的小分子,这对瘤生长至关重要. 化合物5在破坏癌细胞活力和球状体完整性方面表现有希望,为癌症治疗提供了一条新的途径.

关键词:
它具有抗增殖效果的作用.差异化的集群 44 44氨酸是什么? 氨酸是什么?分子动力学模拟的模拟.四化化素的含量是多少三维癌症模型评估评估

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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