类风湿性关节炎中的外围指甲毛细血管显微异常与动脉硬有关:横截面研究的结果
Elena Angeloudi1, Panagiota Anyfanti1, Athanasia Dara2
1Second Medical Department, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Microvascular research
|July 6, 2023
概括
类风湿性关节炎 (RA) 患者表现出广泛的指甲毛细血管检查异常. 这些微血管变化与大动脉硬化相关,这表明NVC可能表明RA的通用血管功能障碍.
科学领域:
- 类风湿病学 类风湿病学
- 心血管医学 心血管医学
- 微循环研究 微循环研究
背景情况:
- 心血管疾病是类风湿性关节炎 (RA) 的重要并发症.
- 爪视频毛囊显微镜 (NVC) 评估了外周微血管结构,但其在RA中的模式尚不清楚.
- 毛细管镜检测结果作为RA全身血管功能障碍标志物的临床意义需要进一步调查.
研究的目的:
- 为了调查RA患者毛细管学模式的流行率和临床意义.
- 探索通过NVC和宏血管功能障碍标志物观察到的微血管变化之间的关联.
主要方法:
- 在连续的RA患者身上进行了标准化的NVC,以评估毛细管密度,无血管区域,尺寸,微出血,静脉,毛细管形态 (分枝,,交叉,曲).
- 测量了关节-关节脉冲波速率 (PWV) 和脉冲压作为大动脉硬化的指标.
- 进行了统计分析,以评估相关性,并根据心血管风险因素和全身炎症进行调整.
主要成果:
- 大多数RA患者 (n=44) 呈现出非特异性和异常NVC发现的组合.
- 毛细管分支与PWV和脉压力显著相关,即使在调整混因子后也是如此.
- 在RA队列中观察到不同毛细管学偏离正常模式的高患病率.
结论:
- 爪视频毛囊镜检查显示,在风湿性关节炎患者中,微血管异常的频率很高.
- 这项研究提供了第一个证据,将结构性微循环障碍与RA中的宏血管功能障碍标志物联系起来.
- 在风湿性关节炎中,NVC可以作为评估通用血管损伤的有价值工具.
相关概念视频
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
17
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
17
Peripheral Artery Disease I: Introduction
10
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs but also impacts other areas, such as the arms, thereby impairing overall circulation and organ function.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty deposits inside the arterial...
10
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
38
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
38
Genome-wide Association Studies-GWAS
13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.6K
Assessment of the Cardiovascular System III: Palpation
387
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
387
Rheumatic Heart Disease I: Introduction
17
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
17


