低剂量计算机断层扫描对有肺癌家族史的亲属进行查
Chi-Liang Wang1, Kuo-Hsuan Hsu2, Ya-Hsuan Chang3
1Division of Pulmonary Oncology and Interventional Bronchoscopy, Department of Thoracic Medicine, Linkou Chang Gung Memorial Hospital, Medical College of Chang Gung University, Taoyuan, Taiwan.
肺癌家族史 (LCFH) 增加了肺癌 (LC) 的风险,特别是在多人家庭和有母亲亲属的家庭. 低剂量计算机断层扫描 (LDCT) 查显示,高危人群中LC检测率为4.5%.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是指放射学
- 遗传学 是一个遗传学.
背景情况:
- 肺癌家族史 (LCFH) 是已知的风险因素.
- 在低剂量计算机断层扫描 (LDCT) 查中,LCFH的潜在作用需要进一步研究.
- 之前的研究并没有对LCFH进行前性评估,在LDCT查中进行长期随访.
研究的目的:
- 通过低剂量计算机断层扫描 (LDCT) 查,前性地研究肺癌 (LCFH) 家族病史在肺癌 (LC) 检测率中的作用.
- 为了确定无症状的第一或二度亲属的肺癌检测率的个人与肺癌的家族史.
- 分析家族史特征对肺癌检测和分期的影响.
主要方法:
- 一项多中心前性研究,涉及多达三次年度LDCT选轮.
- 从2007年到2011年,招募了1102名患有肺癌家族史 (LCFH) 的参与者.
- 长期跟踪至2021年5月5日,以评估肺癌 (LC) 检测率和结果.
主要成果:
- 总体而言,LC检测率为4.5% (50/1102).
- 在多重家庭 (9.4%) 与简单家庭 (3.7%) 相比,观察到更高的检测率.
- 母亲患有LC的病史显著增加了LC的风险 (RR=4.46-5.41).
结论:
- 肺癌家族史 (LCFH) 是肺癌 (LC) 的重要风险因素,特别是在多重家族史和母亲亲属的情况下.
- 在4.5%的LCFH患者中,LDCT查发现了肺癌.
- 需要进一步的随机对照试验来确认LDCT查对LCFH患者的死亡益处.
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