在主要牙科期刊上发表的随机对照试验中报告研究局限性:这是足够的吗?
Simone Stöckli1, Marianna Koufatzidou2, Jadbinder Seehra3
1Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Freiburgstrasse7, CH, 3010, Bern, Switzerland.
Journal of dentistry
|July 6, 2023
概括
在牙科随机对照试验 (RCT) 中报告局限性是不理想的. 改善这种报告对于临床医生来说至关重要,以准确地解释试验结果及其概括性.
科学领域:
- 牙科研究 牙科研究
- 临床试验方法论 临床试验方法论
- 超流行病学 超流行病学
背景情况:
- 临床医生对临床试验结果的准确解释依赖于充分报告研究局限性.
- 本研究涉及牙科随机对照试验 (RCT) 的全文文章中限制的报告质量.
研究的目的:
- 评估主要牙科期刊报告的研究限制程度.
- 探索随机对照试验的特征与报告其局限性之间的关联.
主要方法:
- 一项分析267个随机对照试验 (RCT) 的超流行病学研究,这些研究在2011年,2016年和2021年发表在12个具有影响力的牙科期刊上.
- 数据提取包括RCT特征和报告的局限性存在/不存在.
- 使用无变序逻辑回归来确定试验特征与限制报告之间的关联.
主要成果:
- 发现牙科RCT中关于局限性的报告总体上是低于最佳的.
- 最近的试验和那些公布了协议的试验表明,对局限性的报告更好.
- 牙科日记的类型显著预测了报告的限制.
结论:
- 在牙科随机对照试验中报告研究局限性需要显著改进.
- 关于局限性的明确报告对于评估研究结果的有效性和通用性至关重要.
相关概念视频
Blinding
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...


