使用常规和定量3DMR成像的脑区块重复性和可复制性
J B M Warntjes1,2, P Lundberg3,4, A Tisell3,4
1From the Centre for Medical Image Science and Visualization (J.B.M.W.) marcel.warntjes@cmiv.liu.se.
AJNR. American journal of neuroradiology
|July 6, 2023
概括
从定量MRI数据中合成T1加权的大脑图像,可以实现自动大脑分片. 这种方法显示出高可重复性,但需要进一步优化以减少跨场强度的偏差.
科学领域:
- 放射学 放射学是一门学科.
- 神经成像是一种神经成像.
- 医学物理 医学物理
背景情况:
- 自动大脑分片通常需要专门的MRI序列,增加检查时间.
- 定量MRI (qMRI) 序列可以获得R1,R2和质子密度图.
研究的目的:
- 从qMRI数据中合成T1加权 (T1w) 图像,用于大脑体积测量和分片.
- 用合成图像和传统T1w图像来评估大脑分片的重复性和可重复性.
主要方法:
- 12名受试者使用3D-QALAS和传统T1w序列进行1.5T和3TMRI扫描.
- 合成T1w图像是使用SyMRI从R1,R2和质子密度图生成的.
- 在使用NeuroQuant的传统和合成T1w图像上进行了大脑分片.
主要成果:
- 在传统和合成T1w图像之间观察到很高的相关性 (中位数为0.97在1.5T,0.92在3T).
- 重复性很高,平均变化系数为1.2% (1.5T) 和1.5%-4.4% (3T).
- 在传统方法和合成方法之间,以及跨领域强度之间,注意到了显著的偏差.
结论:
- qMRI数据可用于合成T1w图像堆,用于自动大脑分片.
- 需要对合成参数设置进行进一步调查,以尽量减少观察到的偏差.
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