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治疗耐药抑郁症的功能性MRI标志物:洞察力和挑战

Vasileia Kotoula¹, Jennifer W Evans¹, Claire Punturieri¹

¹Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, MD, United States.

Progress in brain research

|July 6, 2023

概括

神经成像揭示了治疗耐药性抑郁症 (TRD) 中大脑连接和代谢物的改变. 像TMS这样的干预措施有望扭转这些变化,但需要更多的研究才能得出最终的结论.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
医疗成像医学成像

背景情况:

耐治疗抑郁症 (TRD) 是一个重大的临床挑战.
了解TRD的神经生物学基础对于开发有效治疗方法至关重要.

研究的目的:

提供TRD中神经成像发现的概述.
根据大脑变化,识别潜在的治疗点.

主要方法:

综述使用结构磁共振成像 (MRI),功能磁共振 (fMRI) 和磁共振光谱 (MRS) 的研究.

主要成果:

一致的发现表明TRD中脑前部连接性下降和代谢物度变化.
一些干预措施,如跨磁刺激 (TMS),可能会扭转这些神经成像变化.

结论:

神经成像突出了TRD的潜在病理生理机制.
为了推进TRD研究和确定新的治疗目标,更大规模的标准化研究和数据共享至关重要.

关键词:

连接性的连接性电疗法是一种电疗法.功能性核磁共振成像 (MRI) 是一种功能性核磁共振成像.胺基氨酸 (ketamine) 是一种可以磁共振光谱学磁共振光谱学这种药物是psilocybin.结构性核磁共振成像 (MRI)通过骨磁刺激来进行磁性刺激.

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