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Updated: Jul 22, 2026

Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS
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Clinical Testing and Spinal Cord Removal in a Mouse Model for Amyotrophic Lateral Sclerosis ALS

Published on: March 17, 2012

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零星ALS的生存率与脊髓中较低的p62负担有关

Monica Pinkerton1,2, Guinevere Lourenco1,2, Maria Torres Pacheco1

  • 1Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia.

Journal of neuropathology and experimental neurology
|July 6, 2023
PubMed
概括

自标志物p62与肌缩性侧面硬化症 (ALS) 的生存有关. 运动神经元中较高的p62聚合物与较短的存活率相关,这表明p62聚合物.

关键词:
肌缩性侧面硬化症 (AMLS) 是一种疾病.运动神经元 运动神经元p62 病理学 病理学pTDP-43 的时间.

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Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis08:59

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Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...