轴性脊椎关节炎:关于疾病的诊断和治疗的发展概念
Alexandros A Drosos1, Aliki I Venetsanopoulou1, Paraskevi V Voulgari1
1Department of Rheumatology, School of Health Sciences, Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece.
European journal of internal medicine
|July 6, 2023
概括
脊椎关节炎 (SpA) 管理已经发生了变化,早期诊断和向治疗,如TNFα抑制剂,改善了患者的治疗结果和生活质量. 了解疾病病理生理学的进步彻底改变了治疗策略.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 脊椎关节炎 (SpA) 在历史上导致了渐进的疾病,疼痛和结构损伤.
- 在过去的几十年中,脊髓炎患者的治疗选择有限,预后不佳.
- 对SPA的自然历史的理解有了显著的进化.
研究的目的:
- 审查在过去20年间对脊椎关节炎 (SpA) 的理解和管理方面的进展.
- 突出新分类标准和诊断工具对SPA识别的影响.
- 讨论SPA治疗策略的演变,包括向治疗.
主要方法:
- 关于SPA分类,诊断和治疗的最新文献的综述.
- 国际脊柱性关节炎评估协会 (ASAS) 标准的影响分析.
- 评估新型治疗剂的疗效和安全性.
主要成果:
- 现在可以通过ASAS标准和MRI早期诊断SpA,包括各种表型.
- 包括TNFα抑制剂 (TNFi),IL-17和JAK抑制剂在内的向疗法在可接受的毒性下是有效的.
- 现代的SPA管理导致持续的缓解,改善生活质量和预防结构损伤.
结论:
- 在过去的20年里,SPA的概念和管理发生了革命性的变化.
- 早期诊断和向治疗显著改善了SPA的疾病负担.
- 共享决策和先进疗法为SPA患者提供了更好的预后.
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