估计的脉冲波速度与糖尿病风险之间的关联:一个大样本规模队列研究
Wei Bao1, Chunwei Chen2, Chengwen Chen1
1Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221000, China.
概括
估计的脉冲波速度 (ePWV) 与中国成年人患新发糖尿病的风险更高有关. 升高的ePWV可以作为早期糖尿病风险评估的可靠指标.
科学领域:
- 心血管生理学心血管生理学
- 代谢性疾病研究研究
- 公共卫生流行病学 流行病学
背景情况:
- 估计的脉冲波速度 (ePWV) 测量与脉冲波速度 (PWV) 相对应得很好.
- 关于ePWV与患新发糖尿病的风险之间的关联在很大程度上仍未得到研究.
- 了解这种关系对于早期发现糖尿病和预防策略至关重要.
研究的目的:
- 调查ePWV与新发糖尿病风险之间的关联.
- 为了确定ePWV是否是糖尿病发展的独立预测因素.
- 评估ePWV对糖尿病风险的预测价值.
主要方法:
- 一项涉及211,809名中国参与者的队列研究的二次分析.
- 参与者根据ePWV四分之一被分为四个群体.
- 采用多变量考克斯回归和接收器运行特征 (ROC) 曲线分析.
主要成果:
- 在平均3.12年的随访期间,4173名参与者被诊断出患有新发糖尿病.
- 在最高的ePWV四分位数 (Q4) 中,糖尿病发病率显著增加.
- ePWV是新发糖尿病的独立预测因子 (HR,1.233;P<0.001),最佳切断值为8.47m/s.
结论:
- 提升的ePWV独立地与中国成年人患糖尿病的风险增加有关.
- ePWV显示了糖尿病风险的预测价值优于年龄和血压.
- ePWV可以作为早期发现糖尿病风险的有价值和可靠的指标.
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