[上路泌尿道癌患者的手术前化疗:对功能的影响]
P-E Gabriel1, T Lambert1, C Dumont2
1Service d'oncologie médicale, hôpital Saint-Louis, AP-HP-Nord, 1, avenue Claude-Vellefaux, 75010 Paris, France.
概括
对上道泌尿道癌 (UTUC) 的手术前化疗 (POC) 对功能影响最小,并提供有前途的病理反应. 这种方法需要进一步调查工会联合会的管理.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 上道泌尿道癌 (UTUC) 是罕见的,预后不佳.
- 标准的治疗包括管切除术 (NUT) 和辅助化疗.
- 在NUT后的功能衰竭可能会排除化疗,需要采用替代策略.
研究的目的:
- 评估手术前化疗 (POC) 在局部UTUC的疗效和毒性.
- 评估POC对功能和病理反应的影响.
- 探索POC在管理工商联合会中的潜在作用.
主要方法:
- 对24名局部UTUC患者的回顾性分析,这些患者接受了POC治疗.
- 在POC和NUT之前和之后评估功能 (GFR).
- 评估病理反应率和生存结果.
主要成果:
- POC没有显著降低功能 (POC前GFR中位数:70mL/分钟,POC后:77mL/分钟).
- 管切除术 (NUT) 显著降低了功能 (NUT后的GFR中位数:51.5mL/分钟).
- 完整病理反应率为29%,整体存活率为74%,在27.4个月后,无复发存活率为46%.
结论:
- 对于UTUC的POC显示出有利的毒性概况.
- 鼓舞人心的组织学结果表明POC在UTUC治疗中的潜力.
- 建议进行前性研究,以确认POC在工人联合会管理中的作用.
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