在药物活性和瘤对疗法的反应中,Thrombospondin-1
Elisa Longhi1, Laura Carminati1, Elena Carlessi1
1Laboratory of Tumor Microenvironment, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via Stezzano 87, Bergamo 24126, Italy.
Seminars in cell & developmental biology
|July 6, 2023
概括
血栓蛋白质 (TSPs) 调节瘤微环境,并影响癌症治疗反应. 作为生物标志物和治疗点,TSP-1和TSP-2显示出增强抗癌治疗的潜力.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症研究 癌症研究
背景情况:
- 血栓蛋白质 (TSPs) 是多功能蛋白质,对于瘤微环境 (TME) 内的细胞相互作用至关重要.
- TSPs调节癌细胞行为,非新生细胞功能和瘤对环境刺激的反应.
- 它们的上下文依赖的相互作用会影响药物递送,疗效和抗癌疗法的耐药性.
研究的目的:
- 审查TSP,特别是TSP-1在调节瘤对各种抗癌疗法的反应中的多方面的作用.
- 分析TSP对瘤细胞,血管内皮细胞和TME内的免疫细胞的影响.
- 评估TSP作为预后和预测生物标志物以及治疗目标的潜力.
主要方法:
- 文献综述侧重于TSP-1及其在TME中的相互作用.
- 对不同细胞区 (瘤,血管,免疫) 的TSP活性进行分析.
- 检查证据TSP角色的化学疗法,抗血管生成疗法,计量化学疗法,免疫疗法和放射治疗的反应.
主要成果:
- TSPs显著影响瘤对各种治疗方式的反应,结果因细胞环境而异.
- 鉴定TSP-1和TSP-2为预后和预测治疗反应的有价值的生物标志物.
- 了解TSP相互作用为治疗抵抗机制提供了洞察力.
结论:
- TSP在癌症的进展和对治疗的反应中起着关键的,取决于背景的作用.
- 作为癌症预后和治疗疗效的生物标志物,TSP-1和TSP-2具有显著的潜力.
- 针对TSP提供了一个有前途的策略,用于开发新的治疗方法,以提高抗癌治疗结果.
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