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较大的睡眠变化与2型糖尿病中较高的全身炎症有关
Sirimon Reutrakul1, J Jason McAnany2, Jason C Park2
1Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois Chicago, Chicago, Illinois, USA.
Journal of sleep research
|July 6, 2023
概括
在2型糖尿病中,不一致的睡眠模式 (睡眠变化) 与更高的全身炎症有关. 减少睡眠变化可能会改善心脏代谢健康,降低心血管风险.
科学领域:
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
- 睡眠医学 睡眠医学
背景情况:
- 睡眠不规则和变化是已知的心脏代谢疾病的风险因素.
- 系统性炎症,由高灵敏度C反应蛋白 (hs-CRP) 表示,在心血管并发症中起着至关重要的作用.
- 2型糖尿病与心血管风险增加有关,并且经常与睡眠障碍并存.
研究的目的:
- 在2型糖尿病患者中,调查日常睡眠不规则性和可变性与全身炎症 (hs-CRP) 之间的关联.
- 确定睡眠变化是否是hs-CRP水平的独立预测因素,控制其他相关因素.
主要方法:
- 一项试点研究涉及35名患有2型糖尿病的非轮班工作患者.
- 睡眠变化和规律性使用14天的动图测量睡眠持续时间和中点标准偏差的量化.
- 测量了hs-CRP,血红蛋白A1C (HbA1c) 和低密度脂蛋白 (LDL) 水平;通过家庭监测评估睡眠呼吸暂停.
主要成果:
- 较高的睡眠变化与升高的hs-CRP (r=0.342,p=0.044) 有意义地相关.
- HbA1c (r=0.431,p=0.010) 和 LDL (r=0.379,p=0.025) 也与hs-CRP相关.
- 多重回归证实,更高的睡眠变化 (B=0.907,p=0.038) 和HbA1c (B=1.519,p=0.035) 独立预测了更高的hs-CRP水平.
结论:
- 在2型糖尿病患者中,睡眠变化增加与更高的全身炎症独立相关.
- 这一发现表明,睡眠的变化有助于增加这一群体的心血管风险.
- 为了改善心脏代谢健康,需要进一步研究旨在减少变异性的睡眠干预措施.
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