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Updated: Jul 24, 2025

A Simple Guide Screw Method for Intracranial Xenograft Studies in Mice
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蒂尔福斯A9通过抑制PYK2/EGFR-ERK信号通路来减弱质母细胞瘤的生长

Neera Yadav1, Deepak Babu1, Sailaja Madigubba2

  • 1Neuroscience Laboratory, Department of Biotechnology and Bioinformatics, School of Life Sciences, University of Hyderabad, Hyderabad, Telangana, 500 046, India.

Journal of neuro-oncology
|July 6, 2023
PubMed
概括

增加富含林的氨酸激酶-2 (PYK2) 和表皮生长因子受体 (EGFR) 的表达与质母细胞瘤预后不佳相关. 药物Tyrphostin A9 (TYR A9) 有效地抑制了这种信号通路,减少了瘤生长,并在临床前模型中改善了生存率.

关键词:
这是一种抗癌药物.皮表皮肤生长因子受体 (EGFR)质母细胞瘤 (glioblastoma) 是一个富含林的铁氨基激酶-2 (PYK2) 是一种富含林的酶.提尔福斯 A9 A9 提尔福斯 A9

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A Strategy to Identify Compounds that Affect Cell Growth and Survival in Cultured Mammalian Cells at Low-to-Moderate Throughput00:12

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