埃坦塞普特的有效值剂量在患有甲醇抗性类风湿性关节炎的患者中
Fangfang Chen1, Yitian Lang2, Shikai Geng1
1Department of Rheumatology, Ren Ji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Clinical rheumatology
|July 6, 2023
概括
在类风湿性关节炎 (RA) 患者持续缓解时,埃坦塞普特 (ENT) 的有效累积剂量为1975毫克.在耐甲铁沙特的RA中,和剂量策略被证明比非和方法更有效和更具成本效益.
科学领域:
- 类风湿病学 类风湿病学
- 药物经济学 药物经济学
- 临床药理学 临床药理学
背景情况:
- 生物药物已在类风湿性关节炎 (RA) 治疗中取得了先进的进展,但成本昂贵.
- 抗甲基 (MTX) 抗性RA是一种治疗挑战.
- 确定最佳的伊坦塞普特 (ENT) 剂量对于疗效和成本效益至关重要.
研究的目的:
- 确定埃坦塞普特的有效值剂量,以在耐MTX的RA患者中实现持续缓解.
- 在现实环境中评估不同etanercept剂量策略的成本效益.
主要方法:
- 对MTX单独治疗反应不足的患者接受了etanercept.
- 限制性立方线确定了24个月后缓解的累积剂量值 (DAS28-ESR <2.6).
- 在和和非和剂量组之间比较了缓解率,低疾病活性 (LDA) 率,葡萄糖皮质激素的使用,安全性和成本效益.
主要成果:
- 持续缓解的2年累计有效剂量值为1975毫克埃坦塞普特.
- 与非和剂量相比,和剂量策略 (BIW,QW,Q2W/QM) 导致 significantly更高的缓解率和LDA率.
- 和组的增量成本效益比 (ICER) 为5791.2美元/QALY.
结论:
- 累计 1975 毫克的埃坦塞普特剂量有效地在 24 个月内在耐火性 RA 患者中实现持续缓解.
- 在这种患者群体中,和乙太的剂量策略比非和方法更有效和更具成本效益.
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