儿童时期的BMI变化,TXNIP时的DNA甲基化变化,中年期的葡萄糖变化
Hao Ma1, Xuan Wang1, Zhaoxia Liang2
1Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana, USA.
Obesity (Silver Spring, Md.)
|July 6, 2023
概括
在TXNIP的DNA甲基化 (DNAm) 变化与中年期的禁食血葡萄糖 (FPG) 降低有关. 这种关联受到童年和青春期身体质量指数 (BMI) 趋势的影响.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 代谢健康 代谢健康
- 人体生理学 人体生理学
背景情况:
- 基因甲基化 (DNAm) 在基因调节和代谢过程中起着至关重要的作用.
- 以前的研究表明,表观遗传修饰与2型糖尿病等代谢障碍之间存在联系.
- 了解DNAm,血糖控制和早期生活因素之间的相互作用对公共健康至关重要.
研究的目的:
- 调查TXNIP基因DNA甲基化变化与血糖变化之间的关联.
- 为了确定早期的脂肪变化是否会改变TXNIPDNAm与血糖控制之间的关系.
主要方法:
- 从Bogalusa心脏研究中对594名参与者的纵向研究,与中年DNAm测量.
- 分析儿童和青少年时期的身体质量指数 (BMI) 趋势,使用353名参与者的曲线下的增量面积.
- 统计建模以评估TXNIP DNAm变化与快速血葡萄糖 (FPG) 变化之间的关联,调整共变量并测试与BMI趋势的相互作用.
主要成果:
- 在TXNIP中增加的DNA甲基化与禁食血葡萄糖 (FPG) 的下降显著相关 (p < 0.001).
- 根据儿童和青少年时期的BMI趋势,TXNIP DNAm和FPG之间的关联被显著改变 (p-相互作用=0.003).
- 与BMI趋势较高的参与者相比,与BMI趋势较低的参与者相比,TXNIP DNAm每增加1%的FPG减少更大.
结论:
- 血液DNA甲基化TXNIP基因的变化与中年禁食血葡萄糖的变化显著相关.
- TXNIP DNAm与血糖控制之间的关系是由童年和青春期建立的体重指数趋势调节的.
- 这些发现突显了早期肥胖对代谢健康的表观遗传调节的长期影响.
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