使用非负矩阵因子化对默认模式网络的评估,用于因职业暴露引起的认知障碍患者
Feifei Zhang1,2, Bo Liu1,2,3, Yinbo Shao1,3
1Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi Province 030001, P.R. China.
Cerebral cortex (New York, N.Y. : 1991)
|July 6, 2023
概括
长期暴露会对轻度认知障碍 (MCI) 患者的认知,特别是记忆产生负面影响. 默认模式网络 (DMN) 中灰质体积的减少与这种引起的MCI有关.
科学领域:
- 神经科学是一个神经科学.
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
背景情况:
- (Al) 被认为是神经退行性疾病的环境因素.
- 轻度认知障碍 (MCI) 是暴露的潜在后果.
研究的目的:
- 研究引起的MCI患者的结构共变网络中的灰质体积变化.
- 探索血度,认知功能和大脑结构之间的关系.
主要方法:
- 非负矩阵因子化以识别结构共变性网络.
- 相关性分析和群组比较以评估神经结构基础.
- 测量等离子体,MoCA分数和AVLT分数.
主要成果:
- 血度与蒙特利尔认知评估 (MoCA) 和雷雅听力口语学习测试 (AVLT) 的分数呈反向关系.
- 与对照组相比,引起的MCI患者在默认模式网络 (DMN) 中表现出明显较低的灰质体积.
- 在DMN灰质体积和MoCA/AVLT得分之间观察到正相关性.
结论:
- 长期的职业暴露会对认知功能产生不利影响,特别是延迟识别.
- 在DMN中灰质体积减少可能代表引起的MCI的潜在神经机制.
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