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相关概念视频

Passive Diffusion: Overview and Kinetics01:17

Passive Diffusion: Overview and Kinetics

558
Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting...
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Protein Diffusion in the Membrane01:24

Protein Diffusion in the Membrane

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Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...
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Diffusion01:21

Diffusion

4.2K
Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...
4.2K

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相关实验视频

Updated: Jul 24, 2025

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

Published on: December 7, 2021

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修正:使用实验数据和网络扩散来识别活动模块.

Samuel S Boyd1,2, Chad Slawson3,2,4, Jeffrey A Thompson5,6

  • 1Department of Biostatistics and Data Science, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66103, USA.

BMC bioinformatics
|July 6, 2023
PubMed
概括
此摘要是机器生成的。

我们开发了AMEND,这是一种新的算法,可以从分子相互作用数据中识别关键基因子网. 修订有效地发现功能相关的基因组,有助于理解复杂的生物实验.

关键词:
模块识别 模块识别 模块识别网络分析 网络分析俄米克斯 (Omics) 是一个电子游戏.

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Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT
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Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT

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Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks
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Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks

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相关实验视频

Last Updated: Jul 24, 2025

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline
10:44

Inherent Dynamics Visualizer, an Interactive Application for Evaluating and Visualizing Outputs from a Gene Regulatory Network Inference Pipeline

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Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT
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Mapping Molecular Diffusion in the Plasma Membrane by Multiple-Target Tracing MTT

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Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks
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Divergence of Root Microbiota in Different Habitats based on Weighted Correlation Networks

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科学领域:

  • 生物信息学是一种生物信息学.
  • 系统生物学 系统生物学
  • 计算生物学 计算生物学

背景情况:

  • 分子相互作用网络为奥米克实验提供了背景,有助于理解基因表达关系.
  • 在解释实验条件的网络中识别特定的基因子集是一个关键的挑战.
  • 相当变化指数 (ECI) 测量了实验之间的基因调节相似性.

研究的目的:

  • 开发一种新的算法,用于识别功能相关的连接基因子网络.
  • 利用同等变化指数 (ECI) 和网络分析来获得生物洞察力.
  • 在实验数据中找到最能代表潜在生物机制的基因子集.

主要方法:

  • 使用实验数据和网络扩散 (AMEND) 算法开发了主动模块识别.
  • 在蛋白质-蛋白质相互作用 (PPI) 网络中,用于基因权重的随机步行与重新启动.
  • 在最大重量连接子图问题中使用启发式方法来找到最佳子网.

主要成果:

  • AMEND成功地确定了具有高度实验相关性的连接子网络.
  • 算法返回的子网络具有最大的中位数ECI大小.
  • 修改捕获了不同的但相关的功能基因组,证明了它的有效性.

结论:

  • AMEND是一种有效,快速和用户友好的基于网络的活跃模块识别方法.
  • 该算法成功识别了生物相关的基因子网络.
  • 自由可用的代码有助于AMEND在生物研究中的应用.