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药物治疗,饮食障碍的替代和辅助疗法:快速审查的结果
Sarah-Catherine Rodan1,2,3,4, Emma Bryant5, Anvi Le6
1InsideOut Institute for Eating Disorders, Level 2, Charles Perkins Centre (D17), Faculty of Medicine and Health, University of Sydney, Sydney, NSW, 2006, Australia. sarah-catherine.rodan@sydney.edu.au.
Journal of eating disorders
|July 6, 2023
概括
饮食障碍 (ED) 的有效治疗方法有限. 本次审查强调了药物治疗和替代疗法,特别是神经性厌食症的高质量证据的稀缺性,强调需要更多的研究.
科学领域:
- 精神病学和临床心理学
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 饮食障碍 (ED) 是一个重大的公共卫生挑战.
- 目前的治疗方法包括药物疗法,辅助疗法和替代疗法.
- 对证据基础的全面理解对于推进治疗策略至关重要.
研究的目的:
- 总结药物治疗和辅助和替代疗法治疗饮食障碍的证据基础.
- 为澳大利亚国家饮食障碍研究和翻译战略2021-2030提供信息.
- 确定当前研究中的差距,并突出未来研究的领域.
主要方法:
- 采用了快速审查方法.
- 在ScienceDirect,PubMed和Ovid/Medline进行了对2009年至2021年间发表的研究的搜索.
- 优先考虑高水平的证据,包括元分析,大人口研究和随机对照试验,不包括灰色文献.
主要成果:
- 确定了121项研究,重点是药物治疗 (90),辅助疗法 (21) 和替代疗法 (22).
- 对所有类别的干预措施有效性的证据有限,只有很少有高质量的临床试验.
- 具体的发现包括在神经过敏症 (BN) 中对素的一些疗效和在暴饮暴食障碍 (BED) 中对利斯美胺的疗效. 新兴证据表明神经刺激在神经性厌食症 (AN),BN和BED中存在.
结论:
- 发现了对EDs有效的药物和辅助/替代疗法的严重缺乏.
- 对神经性厌食症 (AN) 的有效治疗方法的证据特别稀缺.
- 加强高质量的临床试验活动和药物发现创新对于改善患者结果至关重要.
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