产前暴露于delta-9-tetrahydrocannabinol与 rhesus的DNA甲基化变化有关,这种基因为自闭症基因进行了丰富
Lyndsey E Shorey-Kendrick1, Victoria H J Roberts2, Rahul J D'Mello3
1Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, 97006, USA. shorey@ohsu.edu.
Clinical epigenetics
|July 6, 2023
概括
产前接触食用大麻,特别是delta-9-tetrahydrocannabinol (THC),会改变胎儿和胎盘DNA的甲基化. 这种表观遗传变化影响神经行为发育至关重要的基因,可能会影响长期后代的健康.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展生物学 发展生物学
- 神经科学是一个神经科学.
背景情况:
- 怀孕期间大麻的使用正在增加,这是由于更广泛的可用性和替代的消费方法,如食用食品.
- 产前大麻暴露对胎儿发育的影响在很大程度上是未知的.
研究的目的:
- 调查怀孕期间食用大麻的消费是否会对胎儿和胎盘表观基因组产生负面影响.
- 为了确定产前暴露于delta-9-tetrahydrocannabinol (THC) 引起的特定表观遗传变化.
主要方法:
- 怀孕的 rhesus 每天接受含有THC的食用大麻或安慰剂.
- 在五种组织 (胎盘,肺,小脑,前额叶皮质,心脏) 中使用Illumina MethylationEPIC平台分析了DNA甲基化.
- 分析的重点是针对 rhesus macaque DNA 验证的探针.
主要成果:
- 在子宫内THC暴露导致581个CpG位点的差异性DNA甲基化,其中98%在胎盘中发现.
- 来自SFARI数据库的所有组织的自闭症谱系障碍 (ASD) 候选基因的差异甲基化位点被丰富.
- 胎盘显示了最显著的丰富SFARI基因,包括那些涉及ASD.
结论:
- 产前THC暴露会改变胎盘和胎儿DNA甲基化模式.
- 这些表观遗传变化发生在神经行为发育至关重要的基因中,可能会影响后代的结果.
- 这些发现有助于了解产前大麻使用的风险,并为公共卫生政策提供信息.
相关概念视频
Exon Recombination
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Exon shuffling follows “splice frame rules.” Each exon has three reading...
The Ras Gene
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Ras is a superfamily...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase
Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
Pharmacogenomics: Identification of New Drug Targets
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Human Genetics
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
Biological Causes of Schizophrenia
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.


