血蛋白生物标志物反映了患有重症监护室肺炎的患者宿主反应
Tjitske S R van Engelen1, Tom D Y Reijnders2, Fleur P Paling3
1Center for Experimental and Molecular Medicine (CEMM), Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Room G2-105, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. t.s.vanengelen@amsterdamumc.nl.
Critical care (London, England)
|July 6, 2023
概括
在重症监护室 (ICU) 患有肺炎的重症患者表现出明显的免疫系统变化. 这些包括高度炎症和内皮功能障碍,表明与非肺炎患者相比,宿主反应更严重.
科学领域:
- 关键护理医学 关键护理医学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 免疫抑制与重症患者的肺炎有关.
- 在重症监护室 (ICU) 获得的肺炎可能源于广泛的免疫异常.
- 研究了包括炎症,内皮和凝固在内的宿主反应.
研究的目的:
- 测试ICU获得的肺炎是否与系统性免疫异常有关.
- 为了比较患有和没有ICU获得肺炎的患者的血蛋白生物标志物.
- 为了确定在ICU中肺炎发展之前的主机反应模式.
主要方法:
- 在30家欧洲医院进行了嵌套病例控制研究.
- 包括1997年机械呼吸患者.
- 在入学时测量了19种血蛋白生物标志物,第7天和肺炎诊断.
主要成果:
- 1997年316名患者 (15.8%) 患有肺炎.
- 肺炎病例显示炎症增强和内皮屏障功能受损.
- 生物标志物异常在入学时和在肺炎诊断之前是明显的.
结论:
- 在ICU获得肺炎的重症患者表现出改变的血蛋白生物标志物.
- 这些变化表明更强的促炎,促凝和内皮细胞反应.
- 研究结果表明,在患有ICU肺炎的患者中,系统性宿主反应更为严重.
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