在怀孕期间的两个时间点之间,与妊娠糖尿病相关的表观遗传标记
Teresa Linares-Pineda1,2, Nerea Peña-Montero1, Nicolás Fragoso-Bargas3,4
1Unidad de Gestión Clínica de Endocrinología y Nutrición, Instituto de Investigación Biomédica de Málaga-IBIMA_Plataforma Bionand, Hospital Universitario Virgen de la Victoria, 29010, Málaga, Spain.
Clinical epigenetics
|July 6, 2023
概括
怀孕期间母亲血液中的表观遗传变化可能表明妊娠期糖尿病 (GDM). 确定了特定的DNA甲基化模式,可以作为GDM诊断和预测的生物标志物.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 生殖内分泌学 生殖内分泌学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 不良的子宫内环境,如高血糖症,可以改变母亲和后代的DNA甲基化.
- 孕期糖尿病 (GDM) 是一种严重的妊娠并发症,具有潜在的长期健康影响.
研究的目的:
- 在怀孕期间识别母亲血液中的表观遗传特征.
- 发现妊娠糖尿病 (GDM) 的潜在表观遗传生物标志物.
- 为了确定参与GDM发展的候选基因.
主要方法:
- 在母体外周血液样本上进行全表观基因组关联研究 (EWAS).
- 在两个时间点对32名孕妇 (16名GDM,16名非GDM) 的样本进行分析.
- 在一个独立的群体中验证,该群体来自不同种族 (n=472).
主要成果:
- 272个CpG位点在整个怀孕期间显示了GDM和非GDM组之间的显著差异.
- 不同的甲基化部位与I型糖尿病和胰岛素抵抗的途径有关.
- 三个CpG站点 (cg01459453,cg15329406,cg04095097) 在高精度 (AUC=1) 的控制中区分了GDM.
- 在独立的队列中复制了三个差异甲基化位置 (DMP).
结论:
- 孕妇血液中的表观遗传标记在妊娠期间的GDM病例和对照人群之间存在差异.
- 这些发现表明特定基因在GDM发育中的作用.
- 已识别的CpG位点显示出其作为GDM诊断或预测的敏感和特定生物标志物的潜力.
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