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在围产中风后的EEG功能连接性

Alja Kavčič1,2, Jure Demšar3,4, Dejan Georgiev3,5

  • 1Division of Pediatrics, Department of Neonatology, University Medical Centre Ljubljana, Bohoričeva 20, 1000 Ljubljana, Slovenia.

Cerebral cortex (New York, N.Y. : 1991)
|July 6, 2023
PubMed
概括
此摘要是机器生成的。

患有围产性中风的儿童在几年后显示出大脑功能网络的改变. 这些网络更加分离和同步,具有更高的半球间强度,受损伤体积的影响.

关键词:
功能性大脑网络 功能性大脑网络功能连接性的功能连接性新生儿脑损伤 新生儿脑损伤围产期中风 围产期中风静止状态 EEG 的状态.

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科学领域:

  • 神经科学是一个神经科学.
  • 发育神经科学的发展神经科学.
  • 临床神经学 临床神经学

背景情况:

  • 围产期中风可能导致长期的认知障碍.
  • 这些障碍与大脑功能网络的持久变化有关.
  • 了解这些网络变化对于有针对性的干预至关重要.

研究的目的:

  • 为了研究患有围产中风病史的儿童的功能性大脑连接.
  • 为了比较患有围产中风的儿童和健康对照儿童之间的功能连接体.
  • 探索损伤体积和网络变化之间的关系.

主要方法:

  • 在12名患有围产中风的儿童 (5-14岁) 和16名年龄和性别匹配的健康对照中使用了64通道静止电脑图 (EEG).
  • 计算了每个参与者在α频段中的功能连接体.
  • 分析了中风和对照组之间网络图表指标的差异.

主要成果:

  • 患有围产性中风的儿童在中风后的几年内表现出功能性脑网络的破坏.
  • 脑卒中组的网络更加分离,并显示出更高的同步 (全脑和半球内).
  • 与对照组相比,患有围产期中风的儿童的总半球间强度显著更高,与病变体积相关.

结论:

  • 围产期中风会导致功能性大脑网络的持续干扰,在最初事件发生数年后就能检测到.
  • 网络变化的程度受到大脑损伤的体积的影响.
  • 这些发现凸显了围产期中风对大脑连接和网络组织的长期影响.